A role for mucosal IL-22 production and Th22 cells in HIV-associated mucosal immunopathogenesis

Human Leptin Hormone Affects TNF-α Production in Mucosal-associated Invariant T Cells

Background and Aims: Mucosal-associated invariant T (MAIT) cells are striking lymphocyte population in the blood and their importance in immune responses is growing fast. The current study was conducted to evaluate leptin hormone effects on MAIT cell functions. Materials and Methods: Five healthy male donors in ages of 22-30 years were selected and peripheral blood mononuclear cells (PBMCs) ...

Role of IL-22– and TNF-a–Producing Th22 Cells in Uveitis Patients with Behçet’s Disease

Role of IL-22- and TNF-α-producing Th22 cells in uveitis patients with Behcet's disease.

Behçet's disease is a systemic inflammatory disorder with recurrent episodes of oral ulceration, skin lesions, genital ulceration, and intraocular inflammation (uveitis). The intraocular inflammation is strictly associated with Th effector cells. IL-22 is a member of the IL-10 cytokine family that is involved in inflammatory processes. Recently, Th22 cells were identified as a Th cell populatio...

Enteric mucosa integrity in the presence of a preserved innate interleukin 22 compartment in HIV type 1-treated individuals.

BACKGROUND Interleukin 22 (IL-22) is emerging as a key cytokine for gut epithelial homeostasis and mucosal repair. Gut disruption is a hallmark of human immunodeficiency virus (HIV) infection. Here, we investigated IL-22 production and gut mucosal integrity in HIV type 1 (HIV-1)-infected individuals receiving long-term antiretroviral therapy (ART). METHODS Biopsy specimens from 37 individuals...

Initial HIV mucosal infection and dendritic cells

» DCs thus represent an ideal vehicle to be hijacked by HIV to gain transport to T cells. « HIV hijacks the body’s immune system to have itself delivered to T cells in which it can explosively replicate. It does this partly by subverting the function of various types of dendritic cells (DCs) that are present in many of the tissues exposed to the external environment. To date, however, it has be...